Clinical application in various types of wounds:
Below, we will briefly discuss some of the uses of Atrin wound healing gel.
- Diabetic ulcers
- Bedsore
- Burn wounds
- Surgical wounds
- Superficial cuts and wounds
Article information
- Title:Use of ozone gel in the treatment of various wounds
- Category:Wound articles
- Author:Atrin Med Aseman Research and Development Team
- Copyright:It is okay as long as you cite the source.
Use of ozone gel in the treatment of various types of wounds:
In recent decades, ozone-based therapies have expanded significantly in the field of medicine and wound care due to its unique physiological and biochemical properties. Ozone (O3), as one of the active isomers of oxygen, has antimicrobial, anti-inflammatory and tissue regeneration stimulating properties. The use of ozone in the form of topical gels is considered one of the modern and non-invasive methods in the treatment of acute and chronic wounds. These gels, due to their ability to gradually release active oxygen, improve microcirculation, increase cellular metabolism and accelerate the tissue repair process.
Mechanism of action at the cellular and molecular level:
Ozone, when in contact with damaged tissue, creates a balance between free radicals and antioxidants, providing a suitable biological environment for repair. At the cellular level, ozone activates signaling pathways related to vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF). These processes increase the migration and proliferation of fibroblasts and keratinocytes and stimulate collagen synthesis. At the microbial level, ozone inhibits the growth of pathogens by oxidizing the bacterial cell wall and inactivating vital enzymes. As a result, the wound environment is cleared of contamination and ideal conditions are provided for regeneration.
- Diabetic ulcers
Diabetic ulcers are one of the most complex types of chronic wounds that are difficult to heal due to impaired blood supply, peripheral neuropathy, and recurrent infections. The use of ozone gel increases local oxygenation, stimulates neoangiogenesis, and inhibits the growth of opportunistic bacteria such as Staphylococcus and Pseudomonas. In clinical studies, patients with diabetic foot ulcers have shown a significant reduction in wound size and inflammation severity after two weeks of topical application of ozone gel.
- Bedsore
In long-term hospitalized patients, bedsores are known as one of the most serious complications of constant pressure. Ozone gel accelerates the healing process of these wounds by improving local blood supply and tissue oxygenation. The antibacterial effect of ozone also reduces the microbial load on the wound surface and prevents tissue necrosis. In clinical studies, the use of ozone gel has been reported to reduce the healing time of bedsores by up to 40%.
- Burn wounds
Ozone gel has a significant effect in the treatment of superficial and moderate burns. Ozone prevents the growth of opportunistic microorganisms and increases cellular metabolism, thereby promoting rapid epithelial regeneration. Compared to antibiotic creams, ozone gel does not pose a risk of drug resistance and reduces pain, redness, and inflammation. It also prevents the formation of hypertrophic scars after burn healing.
- Surgical wounds
In post-surgical wound healing, infection control and tissue regeneration are of great importance. Ozone gel reduces the risk of postoperative complications such as infection or suture detachment by creating a sterile environment and stimulating the growth of granulation tissue. Doctors use this gel as a supplementary biological dressing in post-surgical care.
- Superficial cuts and wounds
In everyday cuts and scrapes, ozone gel, with its anti-inflammatory and antibacterial properties, promotes faster wound healing. This gel shortens the healing period by reducing the secretion of wound fluids and facilitating epithelialization. Its regular use prevents the formation of permanent scars and skin discoloration at the wound site.
Advantages over traditional treatments:
Ozone gels have several key advantages over antibiotic ointments and creams. First, they do not develop any drug resistance. Second, they not only control infection but also accelerate the regeneration process. On the other hand, ozone, as a natural agent, is non-cytotoxic and harmonizes with the physiological mechanisms of the body. Ozone gel also improves microcirculation, increases cellular oxygen consumption, and reduces free radicals, which ultimately leads to improved quality of the repaired tissue.
Physiological aspects of wound healing with ozone:
Ozone increases the expression of superoxide dismutase (SOD) and glutathione peroxidase in cells, which are two of the body's most important antioxidant defense systems. As a result, oxidative stress at the wound site is reduced and the healing process is facilitated. Also, by increasing the concentration of ATP in cells, ozone activates the metabolic processes required for cell division and differentiation. These characteristics have made ozone gels one of the most effective topical treatments in the field of wound healing.
Conclusion:
Ozone gels, with their antimicrobial, anti-inflammatory, and tissue-repairing properties, are a novel and effective tool in the treatment of various types of wounds. These products significantly accelerate the healing process by improving oxygenation, increasing neoangiogenesis, stimulating collagen synthesis, and inhibiting infection. Since drug resistance to ozone does not develop, ozone gels can be considered a safe and sustainable alternative to many chemical drugs. With the development of more advanced formulations and extensive clinical studies, the future of using ozone gels in the field of wound healing and skin care looks very bright.
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